Although much progress has been made, 37 million people in the world were living with HIV/AIDS at the end of 2014. This epidemic is the leading cause of death among women of reproductive age. Ending HIV/AIDS requires strategic investments in programs and policies proven to work. Evidence generated over the past 10 years from the PopPov Research Initiative and other findings from sub-Saharan Africa provide insights on the connections between HIV and household and national economics, and on what interventions might contribute to ending the epidemic. This policy brief highlights research on financial and educational interventions that can help reduce new HIV infections.